In 1536, King Henry VIII's request that Thomas Cromwell find a way to rid him of Anne Boleyn - a sentiment supported by others, who wish for Jane Seymour to take her place - leads to a series of allegations and revelations.

In 1535, King Henry VIII's attempt to be declared Head of the Church in England has been denied by the Holy Roman Emperor. Meanwhile, Anne Boleyn's failure to produce a male heir leads Henry toward Jane Seymour.

In 1533, Anne Boleyn has given birth to a daughter, much to King Henry VIII's disdain. As Anne's paranoia over her inability to produce a son grows, Thomas Cromwell tries to convince Sir Thomas More to sanctify the royal marriage.

In 1531, King Henry VIII has proposed a bill which will make him the Head of the Church in England and allow him to marry Anne Boleyn. However, his plans are met with a series of complications.

As 1529 draws to a close, Cardinal Wolsey moves to York while Thomas Cromwell attempts to gain support for him from King Henry VIII and Anne Boleyn, and in the process, gradually wins favor for himself.

In 1529, as Cardinal Wolsey receives news of his dismissal as Lord Chancellor, his lawyer, Thomas Cromwell, reminisces about how he and Wolsey met and the events leading up to the Cardinal's downfall.