Masters and Johnson work to save the practice from disintegrating in the face of insurrection within the clinic. As everyone in their lives either moves on or falls away, Bill and Virginia find solace in one another.

Masters and Johnson return from Topeka, each grappling with the trip's ramifications. Art and Nancy look to tie up loose ends in order to have a fresh start, and Libby embarks on a road trip with Bram that changes her perspective.

Masters and Johnson go on the road and pose as a couple to investigate practices at a competing clinic. While Bill and Virginia are away, Art, Nancy and Langham take advantage of their absence to further their own agendas.

Masters looks to groom Art as his protege in a new area of research as Johnson does her best to keep Nancy at arm's length. Betty seeks an unlikely source for assistance in her fight for equal rights to Helen's baby.

Johnson and Masters' troubles come to a head as the trial begins with Keller leading the charge. Virginia does her best to revive their career as Bill faces the reality of what the charges could mean for him, Johnson and the practice.

Masters and Johnson adjust to new partners, but their respective cases have them second-guessing the instinct to remain separated. A romantic prospect pushes Libby to embrace life as a newly single woman of the sexual revolution.

Masters and Johnson turn to new partners in an effort to put the past behind them and focus on their expanding clinic. Given their fractured triangle, Libby reevaluates her relationship with Bill and Virginia.

On the heels of their disastrous dinner in New York, Masters and Johnson return to find their life's work in jeopardy while under the scrutiny of the press and their publisher in preparation for their new book.

Masters, Johnson, Logan and his wife gather in New York for a dinner in which agendas collide, truths are exposed and no relationship emerges unscathed. Back home, Libby faces an accusation that threatens her family's foundation.

Johnson objects to Masters' program after both Nora and Lester have missteps in the protocol. Meanwhile, as Libby's birthday approaches the men in her life are aiming to please. Plus, Tessa explores what sex really means to her.

Libby tries to mask her feelings by setting Paul up with a friend. Meanwhile, Masters continues his surrogacy program, now under the critical eye of Johnson. And Lester volunteers as their first male surrogate.

As Johnson jets away to Las Vegas with Dan Logan, Masters uses her absence to begin his surrogacy program. Meanwhile, Libby comes to terms with her current and past relationships. And Barton considers starting one of his own.

Masters and Johnson are interviewed by 'Newsweek' as they take on an exotic new patient. Meanwhile, Dan Logan tries to read Virginia. Plus, Libby and Paul deal with the fallout of exposed truths.

As a result of their spreading celebrity, Masters and Johnson take on a famous couple looking to reinvigorate their sex life. Meanwhile, Tessa learns what childhood with Edna Eshelman must ...

Virginia's parents arrive unannounced. Meanwhile, Libby and Masters discover Johnny has been bullied and look to fix it in their own ways. Plus, Johnson finds unexpected excitement in the ...

Masters consults unexpected advice in convincing Johnson to rededicate herself to the study and to him. A familiar face returns to the clinic for help. Meanwhile, Virginia is distracted by ...

Masters and Johnson's book is released and, while reviews are positive, the public's response causes unease around the office. The new spotlight on her mother starts to affect Tessa at ...

The shock waves surrounding Masters and Johnson's first press conference begin to reverberate around their universe as the book nears its release date. Meanwhile, Masters takes on a ...

As Masters and Johnson face the press for the first time, they flashback to summer vacation, where Bill is finishing their book, Virginia faces parenting struggles, and Libby is pulling herself out of a depression. Season premiere.

Masters and Johnson feel ready to cure sexual dysfunction.

A television crew arrives at the clinic to document Masters and Johnson's work treating sexual dysfunction. Masters considers the publicity premature, and himself unsuitable as a television...

Masters learns of a rival study and calls in a public relations expert to help brand his work with Johnson. Virginia, having finally learned of Masters' sexual difficulties, is invigorated ...

Virginia continues to impersonate a patient's case history in order to glean advice from a psychiatrist. Betty and Masters' attempt to remedy Lester's impotence by hiring a prostitute ...

Johnson attempts to treat a woman on her own. Libby witnesses a hate crime.

In the wake of Masters' discovery that Johnson has continued to have romantic relationships with other men, he becomes impotent without her knowledge and cuts off their sexual work together...

After Hendricks bans Masters from using black participants in his study, Masters contacts a journalist to promote his efforts, using the debunking of sexual stereotypes as the lure. Johnson...

Masters continues his study, but loses his gynecology practice; Coral's brother confronts Libby; Betty reunites with a former lover; Johnson tries to fix her relationship with DePaul.

Johnson tries to cover when she and Masters are seen by Langham leaving a hotel together after an evening tryst. Later, Masters attempts to bring Johnson aboard as his assistant at his new ...

Virginia unearths Masters' troubled childhood during a secret rendezvous.

Masters begins a new job at Memorial Hospital - under Betty's terms - only to find his boss insisting he leave Virginia behind in favor of a handpicked secretary. Johnson, meanwhile, still ...

Following Bill's declaration in season 1 finale, Bill and Virginia resume their professional and personal relationship - both asserting it is to further the cause of their work. Virginia ...

Dr. Masters' big day is at hand after 12 months of studies. Without Virginia as a voice of moderation will Bill's pitch hit the mark? Margaret Scully is confronted with her husbands ...

Masters and Libby compile study information for hospital-wide presentation; DePaul and Johnson travel to a medical convention; Virginia's ex returns finds Ethan playing father to his children.

A former study participant comes forward with news of her pregnancy. Ethan learns he has been effectively fired, but not for the reason he thought.

Virginia and Dr. Masters move on to filming involuntary reactions during the study, with Jane as usual being the first subject. Ethan reveals information about his heritage that threatens their relationship.

Virginia resumes pursuit of her undergraduate degree. Masters takes Virginia's suggestion and enlists the aid of a technician to construct a working camera to film the intimate workings during sexual intimacy.

Virginia and William ramp up their participation in the study. Libby bypasses William and pressures Ethan to resume the treatments. Austin and Margaret ramp up their tryst leading to differing expectations. Ethan decides to commit to Vivian.

Bill and Libby vacation in Miami after losing the baby. Virginia attends a visiting doctor's speech and decides to investigate one of the claims on her own. Austin struggles with the reason for his non-performance in the study.

William and Libby experience personal tragedy. Masters decides to pair Austin with a stranger. Virginia struggles with her parenting due to her long hours. Ethan's relationship with Vivian takes the next step, whether he likes it or not.

Both Bill and Virginia have unexpected and unwelcome visitors at home. With the study back in the hospital, new participants are recruited. Ethan struggles to forget his feelings for Virginia.

A woman pregnant with quadruplets comes to the hospital and Dr. Haas lobbies for the case. A female gynecologist joins the staff. Both Dr. Masters and his wife learn a secret and both get what they want.

The Provost shuts down the research when he hears about the couples study and Masters is forced to move it elsewhere. Dr. Masters blames Virginia and fires her, but keeps her on until he can find a replacement.

Dr. William Masters, a successful doctor of obstetrics and gynecology, begins his controversial study of human sexuality. Dr. Masters recruits Virginia Johnson to be his secretary, but she quickly advances to be a valuable associate.